Interstitial Fibrosis in Heart Failure

Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-inv...

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Corporate Author: SpringerLink (Online service)
Other Authors: Villarreal, Francisco J.
Format: Electronic
Language: English
Published: New York, NY : Springer New York, 2005.
Series: Developments in Cardiovascular Medicine, 253
Subjects:
Online Access: http://dx.doi.org/10.1007/b99419
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245 1 0 |a Interstitial Fibrosis in Heart Failure  |h [electronic resource] /  |c edited by Francisco J. Villarreal. 
264 1 |a New York, NY :  |b Springer New York,  |c 2005. 
300 |a XIV, 373 p. 93 illus.  |b online resource. 
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490 1 |a Developments in Cardiovascular Medicine,  |x 0166-9842 ;  |v 253 
505 0 |a Architecture of the Normal and Remodeled Heart -- The Architecture of the Heart: Myocyte Organization and the Cardiac Extracellular Matrix -- Extracellular Matrix and Cardiac Remodeling -- Pro-Inflammatory Cytokines and Cardiac Extracellular Matrix: Regulation of Fibroblast Phenotype -- Pharmacology of G-Protein-linked Signaling in Cardiac Fibroblasts -- Diagnostic Tools for the Identification of Myocardial Fibrosis and Changes in Ventricular Mechanics -- Serum Markers of Fibrillar Collagen Metabolism in Cardiac Diseases -- Ultrasonic Characterization of the Myocardium -- The Mechanics of the Fibrosed/Remodeled Heart -- Pathophysiology of Cardiac Remodeling and Fibrosis -- Renin Angiotensin Aldosterone System and Cardiac Extracellular Matrix -- Matrix Metalloproteinases and Myocardial Remodeling -- Cardiac Mast Cells as Mediators of Ventricular Remodeling -- Matrix Metalloproteinasses in Cardiac Remodeling -- Turmoil in the Cardiac Myocyte: Acute Intracellular Activation of Matrix Metalloproteinases -- Regulation of Cardiac Extracellular Matrix Remodeling Following Myocardial Infarction. -- Experimental Models of MMP Activation: Ventricular Volume Overload -- Prospect for Therapy of the Fibrosed Heart -- Targets for Pharmacological Modulation of Cardiac Fibrosis -- Biological and Functional Effects of Chronic Mechanical Support Induced by Left Ventricular Assist Devices on Failing Human Myocardium -- Molecular Strategies for the Prevention of Cardiac Fibrosis -- Prospects for Gene Therapy for the Fibrosed Heart: Targeting Regulators of Extracellular Matrix Turnover -- Therapeutic Potential of TIMPs in Heart Failure. 
520 |a Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment. 
650 0 |a Medicine. 
650 0 |a Cardiology. 
650 0 |a Cardiac surgery. 
650 1 4 |a Medicine & Public Health. 
650 2 4 |a Cardiology. 
650 2 4 |a Cardiac Surgery. 
700 1 |a Villarreal, Francisco J.  |e editor. 
710 2 |a SpringerLink (Online service) 
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776 0 8 |i Printed edition:  |z 9780387228242 
830 0 |a Developments in Cardiovascular Medicine,  |x 0166-9842 ;  |v 253 
856 4 0 |u http://dx.doi.org/10.1007/b99419 
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950 |a Medicine (Springer-11650) 
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